From Metamodern, Drexler himself has commented on what I've been thinking for a few months now: http://metamodern.com/2009/12/15/when-a-million-readers-first-encountered-nanotechnology/ http://metamodern.com/2009/12/19/molecular-manufacturing-where%E2%80%99s-the-progress/ http://metamodern.com/2009/12/25/the-molecular-machine-path-to-molecular-manufacturing-1/ http://metamodern.com/2009/12/27/the-molecular-machine-path-2-exploiting-better-methods-and-building-blocks/ http://metamodern.com/2009/12/29/theres-plenty-of-room-at-the-bottom%E2%80%9D-feynman-1959/ This quote probably sums it all up the best: "The progress I have in mind centers on advances in atomically precise fabrication by chemical and biological means, and these advances now have reached a level that places the implementation of first-generation artificial APM systems within reach. These, however, also won’t resemble slick, large-scale, general-purpose HT-APM systems. Instead, they will support the implementation...